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So called matrix effects often dictate that samples be analyzed by LC/MS since their presence with analyte leads to inefficient ionization or formation of adducts. The effect of various solvents on DART® efficiency is show here using the common standard Warfarin.
The DART® ionized molecule appears as the protonated molecule and the spectrum is virtually adduct free.
Chemical ionization is easily accomplished with DART. Simply add ammonium hydroxide vapor near the sample to generate the ammonium addict as shown with Warfarin here.