Organic synthesis and drug discovery communities are shifting towards high throughput screening and optimizing reaction conditions in arrays of 96 or 384 to meet stringent timelines. As analytical methods, such as DART, are becoming faster, the limitation on throughput falls on the time the MS software needs to initialize and close individual files for each sample. All samples therefore need to be acquired in a single data file, which consequently complicates the data analysis.
Automatic peak detection in AnalyzerProXD (developed by SpectralWorks) allows for parsing of large quantities of samples in a single data file to be separated into separate data files for post acquisition processing. Analysis of 384 samples with DART-MS takes less than 25 minutes. Following analysis with parsing by AnalyzerProXD software for post acquisition processing, detecting targeted compounds in heat mapping format of the 384 well plate takes ~ 2 minutes. This leads to total analysis and sample processing time for 384 samples screening to be less than 30 minutes. AnalyzerProXDalso offers statistical analysis and facilitated quantitation for post acquisition sample processing.
Watch SpectralWorks video on how to use AnalyzerPro XD with DART data!
Check out our application note for Contaminant Detection simplified with AnalyzerPro XD software combined with our JumpShot-HTS package!