Publications

DART® mass spectrometry, rapid analysis of soft medicinal formulations

Authors: Elena S. Chernetsova, Rimma A. Abramovich
Pharmaceutical Chemistry Journal 2012, Mar, 15, 45(11), 1-3
10.1007/s11094-012-0705-4
 

The possibility of using the DART® mass spectrometry method for rapid analysis of soft medicinal formulations is considered. Studies ...


Optimization of direct analysis in real time (DART®) linear ion trap parameters for the detection and quantitation of glucose

Authors: Daudi S. Saang'onyo, Darrin L. Smith
Rapid Communications in Mass Spectrometry 2012, Feb, 01, 26 (3), 385-91
10.1002/rcm.5316
 
Presented here are findings for the development and optimization of a simple, high-throughput, and rapid method for the analysis of ...

Analysis of Alprazolam by DART®-TOF Mass Spectrometry in Counterfeit and Routine Drug Identification Cases

Authors: Warren C. Samms, Yongyi Julia Jiang , Mark D. Dixon, Stephen S. Houck, Ashraf Mozayani
Journal of Forensic Sciences 2011, Jul, 01, Volume 56, Issue 4, 993–998
10.1111/j.1556-4029.2011.01767.x
 
The high prevalence of alprazolam abuse translates to an increased workload for crime laboratories in characterizing seized tablets. These ...

Microwave-Assisted Solution-Phase Synthesis and DART®-Mass Spectrometric Monitoring of a Combinatorial Library of Indolin-2,3-dione Schiff Bases with Potential Antimycobacterial Activity

Authors: Tarek Aboul-Fadl, Hatem A. Abdel-Aziz, Adnan Kadi, Pervez Ahmad, Tilal Elsaman, Mohamed W. Attwa, Ibrahim A. Darwish
Molecules 2011, Jun, 22, 16(6), 5194-206
 
A combinatorial library composed of eleven hydrazides A-K and eleven indolin-1,2-dione derivatives 1-11 has been designed to formally ...

Direct analysis in real time coupled with dried spot sampling for bioanalysis in a drug-discovery setting

Authors: Elizabeth Crawford, Brian Musselman, Shaoxia Yu, Jing-Tao Wu, Justin Gordon, Ray Liu
Bioanalysis 2011, Jun, 01, 3(11), 1217-26
 
BACKGROUND:
Conventional mouse or rat pharmacokinetic/toxicokinetic (PK/TK) studies frequently require sacrifice or use of multiple ...

Purification of pharmaceutical preparations using thin-layer chromatography to obtain mass spectra with Direct Analysis in Real Time and accurate mass spectrometry

Authors: Robert R. Steiner, Jessica L. Wood
Drug Testing and Analysis 2011, Jun, 01, Volume 3, Issue 6, 345–351
10.1002/dta.293
 
Forensic analysis of pharmaceutical preparations requires a comparative analysis with a standard of the suspected drug in order to identify ...

Detection of illicit drugs on surfaces using direct analysis in real time (DART®) time-of-flight mass spectrometry

Authors: Andrew H. Grange, Wayne Sovocool
Rapid Communications in Mass Spectrometry 2011, May, 15, Volume 25, Issue 9, 1271–1281
10.1002/rcm.5009
 
Methamphetamine (meth) from meth syntheses or habitual meth smoking deposited on household surfaces poses human health hazards. The U.S. ...

New approach to detecting counterfeit drugs in tablets by DART® mass spectrometry

Authors: Elena S. Chernetsova, Pavel O. Bochkov, Rimma A. Abramovich
PHARMACEUTICAL CHEMISTRY JOURNAL 2011, May, 01, 45(5), 306-308
10.1007/s11094-011-0622-y
 
The possibility of using DART® mass spectrometry for the identification of active ingredients in tableted drugs has been studied. ...

Principal component directed partial least squares analysis for combining nuclear magnetic resonance and mass spectrometry data in metabolomics, Application to the detection of breast cancer

Authors: Brian Musselman, Haiwei Gu, Zhengzheng Pan, Bowei Xi, Vincent Asiago, Daniel Raftery
Analytica Chimica Acta 2011, Feb, 01, 686(1-2), 57–63
10.1016/j.aca.2010.11.040
 
Nuclear magnetic resonance (NMR) spectroscopy and mass spectrometry (MS) are the two most commonly used analytical tools in metabolomics, ...

Ambient desorption ionization mass spectrometry (DART®, DESI) and its bioanalytical applications

Authors: Zoltán Takáts, Justin M Wiseman, R Graham Cooks
Journal of mass spectrometry 2011, Jan, 05, 40, Issue: 10, 1261-75
10.1002/jms.922
 
Analytical characteristics of DESI are summarized. Examples of applications to small and large molecules, to in situ analysis, and to ...

Epiafzelechin from the Root Bark of Cassia sieberiana, Detection by DART® Mass Spectrometry, Spectroscopic Characterization, and Antioxidant Properties

Authors: Kafui Kpegba, Amegnona Agbonon, Ana Petrovic, Etchri Amouzou, Messanvi Gbeassor, Gloria Proni, Nasri Nesnas
Journal of Natural Products 2010, Nov, 11, ,
10.1021/np100090e
 
The root bark of Cassia sieberiana was analyzed using direct analysis in real time mass spectrometry, and a main flavonoid component with ...

Identification of marker compounds in herbal drugs on TLC with DART®-MS

Authors: Hye Jin Kim, Young Pyo Jang, Eun Hye Jee, Kwang Sung Ahn, Hyo Sook Choi
Archives of Pharmacal Research 2010, Sep, 01, 33(9), 1355-1359
10.1007/s12272-010-0909-7
 
This study was conducted to provide a more versatile and specific information on Thin Layer Chromatographic (TLC) analysis of medicinal ...

DART® mass spectrometry, a fast screening of solid pharmaceuticals for the presence of an active ingredient, as an alternative for IR spectroscopy

Authors: Elena S. Chernetsova, Pavel O. Bochkov, Maxim V. Ovcharov, Sergey S. Zhokhov, Rimma A. Abramovich
Drug Testing and Analysis 2010, May, 27, 2(6), 292–294
10.1002/dta.136
 
The application of DART® as a choice analytical tool for rapid analysis of counterfeit pharmaceuticals is discussed. DART® ...

Small Molecule Ambient Mass Spectrometry Imaging by Infrared Laser Ablation Metastable-Induced Chemical Ionization

Authors: Asiri Galhena, Glenn Harris, Leonard Nyadong, Kermit Murray, Facundo Fernndez
Analytical Chemistry 2010, Feb, 15, 82(6), 2178-2181
0.1021/ac902905v
 
Presented here is a novel ambient ion source termed infrared laser ablation metastable-induced chemical ionization (IR-LAMICI). IR-LAMICI ...

Ambient Pressure Desorption Ionization Mass Spectrometry in Support of Preclinical Pharmaceutical Development

Authors: Roy Helmy, Brian Musselman, Wes Schafer, Leah Buhler, Stephen Marcinko, Erin Guidry, Herb Jenkins, Fred Fleitz, Christopher Welch
Org. Process Res. Dev. 2010, Feb, 10, 14 (2), 386–392
DOI: 10.1021/op9002938
 
The use of ambient pressure desorption ionization mass spectrometry
for the rapid analytical support of process and pharmaceutical

Optimization of a Direct Analysis in Real Time,Time-of-Flight Mass Spectrometry Method for Rapid Serum Metabolomic Fingerprinting

Authors: Manshui Zhou, John F. McDonald, Facundo Fernndez
Journal of the American Society for Mass Spectrometry 2010, Jan, 01, 21(1), 68-75
10.1016/j.jasms.2009.09.004
 
Metabolomic fingerprinting of bodily fluids can reveal the underlying causes of metabolic disorders associated with many diseases, and has ...

Bioanalysis without Sample Cleanup or Chromatography, The Evaluation and Initial Implementation of Direct Analysis in Real Time Ionization Mass Spectrometry for the Quantification of Drugs in Biological Matrixes

Authors: Elizabeth Crawford, Brian Musselman, Joe Tice, Shaoxia Yu, Jing-Tao Wu
Analytical Chemistry 2009, Mar, 10, 81(1), 193-202
10.1021/ac801734t
 
Two key bottlenecks in pharmaceutical bioanalysis are sample cleanup and chromatographic separations. Although multiple approaches have ...